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P007

Peptide ID

PEPTIDE001039

Raw sequence

N-(RXRRXRRXRRXRXB)-C (X=6-aminohexanoic acid; B=β-alanine)

Clean backbone

RAHXRRAHXRRAHXRRAHXRAHXBLA

Tokenized backbone

R-AHX-R-R-AHX-R-R-AHX-R-R-AHX-R-AHX-BLA

Sequence engineering

Stereochemistry

Modifications

Arginine-rich CPP with non-natural residues (6-aminohexanoic acid, β-alanine); covalent to PMO

Sequence length

26

Noncanonical residues

Experiments

• EXP001275 from Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic…