Ac-(HS)XLRKLRKRLLRXC-NH2 (as shown in paper schematic)
Clean backbone
AAHXLRKLRKRLLRAHXCNH
Tokenized backbone
A-AHX-L-R-K-L-R-K-R-L-L-R-AHX-C-N-H
Sequence engineering
Stereochemistry
Modifications
Valproic acid coupled via hydrolysable ester linkage (HMBA-based linker) at N-terminus; C-terminal cysteine-amide; covalent conjugation to 3′-maleimido-PMO via thiol–maleimide.