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(R-Ahx-R)4–PNA705 (stable)

Peptide ID

PEPTIDE001293

Raw sequence

R-Ahx-RR-Ahx-RR-Ahx-RR-Ahx-R-C

Clean backbone

RAHAHXRRAHAHXRRAHAHXRRAHAHXRC

Tokenized backbone

R-A-H-AHX-R-R-A-H-AHX-R-R-A-H-AHX-R-R-A-H-AHX-R-C

Sequence engineering

Stereochemistry

Modifications

Oligoarginine with aminohexanoic (Ahx) spacers; thioacetyl (S-CH2) linkage to PNA705 (Table 1).

Sequence length

29

Noncanonical residues

Experiments

• EXP001682 from Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery p…