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Octaarginine (R8) in DSPE-PEG2000-R8 (post-inserted)

Peptide ID

PEPTIDE001302

Raw sequence

Ac-Cys-βAla-(Arg)8-H (R8 peptide used to synthesize DSPE-PEG2000-R8)

Clean backbone

CBLARRRRRRRRH

Tokenized backbone

C-BLA-R-R-R-R-R-R-R-R-H

Sequence engineering

Stereochemistry

Modifications

R8 CPP attached to DSPE-PEG2000 via maleimide-thiol coupling; DSPE-PEG2000-R8 post-inserted (20 mol% relative to CD) onto preformed SC12CDclickpropylamine/siRNA complexes (MR20).

Sequence length

13

Noncanonical residues

Experiments

• EXP001694 from In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modifie…