R8 = (Arg)8 (Fmoc-[R(Pbf)]8-COOH precursor); conjugated to PEI via amide bond
Clean backbone
RRRRRRRR
Tokenized backbone
R-R-R-R-R-R-R-R
Sequence engineering
Stereochemistry
Modifications
Octa-arginine (R8) CPP covalently grafted onto PEI 25k via carbodiimide coupling (amide bond). Deprotected after TFA/TIS/H2O treatment. Used to complex siRNA at N/P=40.