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DG9

Peptide ID

PEPTIDE001875

Raw sequence

N-YArVRRrGPRGYArVRRrGPRr-C

Clean backbone

NYAVRRGPRGYAVRRGPRC

Tokenized backbone

N-Y-A-V-R-R-G-P-R-G-Y-A-V-R-R-G-P-R-C

Sequence engineering

Stereochemistry

D-form

Modifications

CPP; mixed L/D Arg (lowercase r = D-Arg); covalently conjugated to 3′ end of PMO

Sequence length

19

Noncanonical residues

Experiments

• EXP002435 from DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via…
• EXP002436 from DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via…