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GALA/PEG2000-MENDssPalmE / anti-CD31 siRNA

Peptide ID

PEPTIDE001893

Raw sequence

WEAALAEALAEALAEHLAEALAEALEALAA

Clean backbone

WEAALAEALAEALAEHLAEALAEALEALAA

Tokenized backbone

W-E-A-A-L-A-E-A-L-A-E-A-L-A-E-H-L-A-E-A-L-A-E-A-L-E-A-L-A-A

Sequence engineering

pH-responsive amphipathic α-helical GALA peptide used as lung-endothelium targeting ligand and endosomal escape peptide; conjugated to PEG2000-lipid via Cys-GALA/DSG-PEG2000-MAL for surface post-modification of MENDssPalmE

Stereochemistry

L-amino acids inferred; no D-amino acids reported

Modifications

PEGylated GALA; GALA/PEG2000 ligand on MENDssPalmE surface; cysteine-terminated GALA used for maleimide conjugation to DSG-PEG2000-MAL

Sequence length

30

Noncanonical residues

Experiments

• EXP002473 from PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarr…