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WRAP4
- Peptide ID
- PEPTIDE001921
- Raw sequence
- LLRLLRWWRLLRLL
- Clean backbone
- LLRLLRWWRLLRLL
- Tokenized backbone
- L-L-R-L-L-R-W-W-R-L-L-R-L-L
- Sequence engineering
- 14-mer W/R-rich amphipathic peptide; clustered tryptophan design; +5 charge; complexed siRNA but showed variable knockdown mainly at high peptide:siRNA ratio.
- Stereochemistry
- L-amino-acid synthetic CPP; no D-amino acids reported
- Modifications
- No covalent RNA conjugation; noncovalent WRAP/siRNA nanoparticle formation
- Sequence length
- 14
- Noncanonical residues
Experiments