siRNA

Linked experiment: EXP000517

Linked peptide: HE25

Linked paper: A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication (2024)

RNA overview

RNA Type: siRNA
Payload/target: SARS-CoV-2 RdRp (biodistribution and silencing surrogate)
Target gene/transcript: sars-cov-2

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:Ggaaggaaguucuguugaa+T+Tt; antisense:uucaacagaacuuccuucc+T+Tt
Sense strand: Ggaaggaaguucuguugaa+T+Tt
Antisense strand: uucaacagaacuuccuucc+T+Tt

Chemical modifications

RNA modifications: Alexa Fluor 555-labeled siRNA; 125I-labeled peptide in biodistribution