siRNA

Linked experiment: EXP000606

Linked peptide: pepR

Linked paper: siRNA–cell-penetrating peptide complexes as a combinatorial therapy against chronic myeloid leukemia (2017)

RNA overview

RNA Type: siRNA
Payload/target: siRNA-CF-1/2/3/4/5
Target gene/transcript: Bcr-Abl1

Sequence information

Sequence reported in source article: yes
RNA sequence: multiple Bcr-Abl1 siRNAs tested: siRNA-CF-1; siRNA-CF-2; siRNA-CF-3; siRNA-CF-4; siRNA-CF-5
Sense strand: CUUCGAGCGGAUCCGCAAGtt; GGAAGAAGCCCUUCAGCGGtt; ACACCCUAACCUGGUGCAGtt; GCUGGAAAGGGCAGUGCCUtt; AGGGCAGUGCCUUAGGGACtt
Antisense strand: CUUGCGGAUCCGCUCGAAGtt; CCGCUGAAGGGCUUCUUCCtt; CUGCACCAGGUUAGGGUGUtt; AGGCACUGCCCUUUCCAGCtt; GUCCCUAAGGCACUGCCCUtt

Chemical modifications

RNA modifications: standard siRNA (custom designed); 3' tt overhang