SCO

Linked experiment: EXP000786

Linked peptide: Tat

Linked paper: Induction of splice correction by cell-penetrating peptide nucleic acids (2006)

RNA overview

RNA Type: SCO
Payload/target: β-globin intron 2 aberrant splice site in luciferase reporter (HeLa pLuc 705) (M705 splice-correcting PNA)
Target gene/transcript: luciferase

Sequence information

Sequence reported in source article: no
RNA sequence: not reported
Sense strand
Antisense strand

Chemical modifications

RNA modifications: PNA M705: CysKKCCTCTTACCTCAGTTACAKK-NH2; inverted control (4 bases inverted). Some conjugates fluorescein-labeled on C-terminal Lys for uptake assays.