siRNA

Linked experiment: EXP000950

Linked peptide: Octreotide (N3-Oct) + Tat(49–57) CPP (N3-CPP)

Linked paper: A one-pot modular assembly strategy for triple-play enhanced cytosolic siRNA delivery (2019)

RNA overview

RNA Type: siRNA
Payload/target: survivin mRNA (cpusiRNA2)
Target gene/transcript: survivin; cpu

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:GAAUUUGAGGAAACUGCGATT; antisense:TTCUUAAACUCCUUUGACGCU
Sense strand: GAAUUUGAGGAAACUGCGATT
Antisense strand: TTCUUAAACUCCUUUGACGCU

Chemical modifications

RNA modifications: sense: 5′-GAAUUUGAGGAAACUGCGAtt-3′; antisense: 3′-ttCUUAAACUCCUUUGACGCU-5′ (as reported); also used FAM-siRNA and Cy5-siRNA for uptake/biodistribution