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oligonucleotide

Linked experiment: EXP000970

Linked peptide: P4

Linked paper: Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery (2024)

RNA overview

RNA Type

oligonucleotide

Payload/target

ERα (estrogen receptor alpha) decoy / target protein: ERα

Target gene/transcript

not reported

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:GTCAGGTCACAGTGACCTGATCAAAGTTAA; antisense:uuaacuuugATCAGGTCACTGTGTGACCTGAC

Sense strand

GTCAGGTCACAGTGACCTGATCAAAGTTAA

Antisense strand

uuaacuuugATCAGGTCACTGTGTGACCTGAC

Chemical modifications

RNA modifications

LCL161 (IAP ligand) conjugated; P4 directly conjugated to LCL-ER(dec) (LCL-ER(dec)-P4)