siRNA

Linked experiment: EXP001092

Linked peptide: CPP

Linked paper: Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells (2022)

RNA overview

RNA Type: siRNA
Payload/target: Bcl-2 (siRNA) knockdown in HepG2
Target gene/transcript: bcl-2

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:GUGAUGAAGUACAUCCAUUdTdT; antisense:AAUGGAUGUACUUCAUCACdTdT
Sense strand: GUGAUGAAGUACAUCCAUUdTdT
Antisense strand: AAUGGAUGUACUUCAUCACdTdT

Chemical modifications

RNA modifications: Bcl-2 siRNA duplex (sense 5′-GUGAUGAAGUACAUCCAUUdTdT-3′; antisense 5′-AAUGGAUGUACUUCAUCACdTdT-3′); CPP conjugated via disulfide to thiol-modified sense (C-siRNA).