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ASO

Linked experiment: EXP001329

Linked peptide: N/A (DNA tetrahedron vector; no peptide carrier)

Linked paper: Tetrahedral DNA Nanoparticle Vector for Intracellular Delivery of Targeted Peptide Nucleic Acid Antisense Agents to Restore Antibiotic Sensitivity in Cefotaxime-Resistant Escherichia coli (2017)

RNA overview

RNA Type

ASO

Payload/target

blaCTX-M-group 1 (CTX-M β-lactamase) mRNA (field isolate harbors blaCTX-M-3 plasmid)

Target gene/transcript

not reported

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:ttccttattctgg

Sense strand

ttccttattctgg

Antisense strand

Chemical modifications

RNA modifications

PNA4 13-mer base sequence (5'→3'): ttccttattctgg