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siRNA

Linked experiment: EXP001347

Linked peptide: CTX-R10 (chlorotoxin + deca-arginine)

Linked paper: Iron oxide nanoparticles decorated with functional peptides for a targeted siRNA delivery to glioma cells (2022)

RNA overview

RNA Type

siRNA

Payload/target

MGMT siRNA (therapeutic target; chemoresistance sensitization) and siRFP reporter siRNA (validation in C6 cells)

Target gene/transcript

MGMT

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:CCUUCAUCUACCACGUGAAdTdT

Sense strand

CCUUCAUCUACCACGUGAAdTdT

Antisense strand

Chemical modifications

RNA modifications

Thiol-modified siRNA used for fluorescent labeling (BDP-maleimide, 1:1.2); Cy5-NHS labeling used for NP tracking (per Supplementary Methods).