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ASO

Linked experiment: EXP001476

Linked peptide: R4-Tat

Linked paper: Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides (2005)

RNA overview

RNA Type

ASO

Payload/target

HIV-1 TAR RNA (steric block of Tat/TAR; reporter assay) | 12mer 2'-O-methyl/LNA mixmer anti-TAR: 5'-CUC CCA GGC UCA-3' (mixmer; 3' fluorescein; 5' C6-thiol linker)

Target gene/transcript

TAR

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:CUCCCAGGCUCA

Sense strand

CUCCCAGGCUCA

Antisense strand

Chemical modifications

RNA modifications

3' fluorescein label; 5' C6-thiol linker; OMe/LNA mixmer or phosphorothioate as specified.