SCO

Linked experiment: EXP001486

Linked peptide: RXR6-4B

Linked paper: Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides (2010)

RNA overview

RNA Type: SCO
Payload/target: PNA705 splice-switching (pLuc705 luciferase reporter intron correction)
Target gene/transcript: luciferase

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:sCCTCTTACCTCAGTTACA; antisense:CCTCTTACCTCAGTTACA
Sense strand: sCCTCTTACCTCAGTTACA
Antisense strand: CCTCTTACCTCAGTTACA

Chemical modifications

RNA modifications: PNA705 18-mer (CCTCTTACCTCAGTTACA) with N-term Cys(NPys)-Lys and C-term Lys-amide; disulfide conjugated to peptide Cys