siRNA

Linked experiment: EXP001565

Linked peptide: Tat-PAMAM G5 dendrimer (BPT)

Linked paper: Tat-Conjugated PAMAM Dendrimers as Delivery Agents for Antisense and siRNA Oligonucleotides (2005)

RNA overview

RNA Type: siRNA
Payload/target: MDR1 coding region nt 1545–1565 (ORF1 siRNA)
Target gene/transcript: ORF1

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:GUAUUGACAGCUAUUCGAAdTdT; antisense:dTdTCAUAACUGUCGAUAAGCUU
Sense strand: GUAUUGACAGCUAUUCGAAdTdT
Antisense strand: dTdTCAUAACUGUCGAUAAGCUU

Chemical modifications

RNA modifications: Duplex siRNA with dTdT overhangs; Cy5-labeled version used for imaging; mismatch/irrelevant control (Nischarin) used