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siRNA

Linked experiment: EXP001619

Linked peptide: PCL-R15 (PCL3000-b-R15 amphiphilic block polymer)

Linked paper: Polyarginine-Mediated siRNA Delivery: A Mechanistic Study of Intracellular Trafficking of PCL-R15/siRNA Nanoplexes (2020)

RNA overview

RNA Type

siRNA

Payload/target

siNC

Target gene/transcript

VEGF; anti-VEGF

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:GGAGUACCCUGAUGAGAUCTT

Sense strand

GGAGUACCCUGAUGAGAUCTT

Antisense strand

Chemical modifications

RNA modifications

Unlabeled for silencing; FAM/Cy3/Cy5-labeled scrambled siRNA used for uptake/trafficking/FRET in mechanistic assays (5′ label on sense strand).