siRNA

Linked experiment: EXP001620

Linked peptide: PCL-R15 (PCL3000-b-R15 amphiphilic block polymer)

Linked paper: Polyarginine-Mediated siRNA Delivery: A Mechanistic Study of Intracellular Trafficking of PCL-R15/siRNA Nanoplexes (2020)

RNA overview

RNA Type: siRNA
Payload/target: siNC
Target gene/transcript: VEGF; anti-VEGF

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:UUCUCCGAACGUGUCACGUTT; antisense:ACGUGACACGUUCGGAGAATT
Sense strand: UUCUCCGAACGUGUCACGUTT
Antisense strand: ACGUGACACGUUCGGAGAATT

Chemical modifications

RNA modifications: FAM/Cy3/Cy5 labels on 5′ end of sense strand used for uptake/trafficking/FRET; unlabeled for control in silencing assay.