Back to browse

siRNA

Linked experiment: EXP001628

Linked peptide: R8-PEI (octaarginine-modified PEI 25k)

Linked paper: Targeted melanoma therapy: High-efficiency siRNA delivery with R8-PEI dissolvable microneedles (2025)

RNA overview

RNA Type

siRNA

Payload/target

BRAF siRNA (siRNA-4 selected; methoxylation-modified for stability) targeting BRAF in A375 melanoma

Target gene/transcript

BRAF in A375 melanoma; BRAF

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:CAAACAGAGGACAGUGGUA

Sense strand

CAAACAGAGGACAGUGGUA

Antisense strand

Chemical modifications

RNA modifications

Methoxylation modification (to enhance stability); Cy3-labeled siRNA used for uptake/escape imaging