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siRNA

Linked experiment: EXP001642

Linked peptide: TAT(48-60)

Linked paper: Lung Delivery Studies Using siRNA Conjugated to TAT(48-60) and Penetratin Reveal Peptide Induced Reduction in Gene Expression and Induction of Innate Immunity (2007)

RNA overview

RNA Type

siRNA

Payload/target

A/B/C siRNA; MM1/MM2 controls

Target gene/transcript

A/B/C

Sequence information

Sequence reported in source article

yes

RNA sequence

A/B/C siRNAs tested; MM1/MM2 mismatch controls reported

Sense strand

GCACACUGAUGAUGAGAUGUU; ACAUUCGGCUGACAUAAUUUU; GGGAGGUGCCCGAACGAUAUU; CCGAGGUGGCGGAACGAUAUU; GCGAGCUGCGCGAAGGAUAUU

Antisense strand

CAUCUCAUCAUCAGUGUGCUU; AAUUAUGUCAGCCGAAUGUUU; UAUCGUUCGGGCACCUCCCUU

Chemical modifications

RNA modifications

Sense strand 5' C6-thiol linker; disulfide-linked peptide–siRNA conjugate (sense strand); duplex annealed