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siRNA

Linked experiment: EXP001726

Linked peptide: Proteinticle(ECP+CAP+CPP) (CTP-free)

Linked paper: Engineered Proteinticles for Targeted Delivery of siRNA to Cancer Cells (2015)

RNA overview

RNA Type

siRNA

Payload/target

Poly-siRNA (uptake assay)

Target gene/transcript

Poly-

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:UGUAGAUGGACUUGAACUC; antisense:GAGUUCAAGUCCAUCUACA

Sense strand

UGUAGAUGGACUUGAACUC

Antisense strand

GAGUUCAAGUCCAUCUACA

Chemical modifications

RNA modifications

RFP siRNA sense UGUAGAUGGACUUGAACUCdTdT; antisense GAGUUCAAGUCCAUCUACAdTdT. Scrambled control sense UGAAGUUGCACUUGAAGUCdTdT; antisense GACUUCAAGUGCAACUUCAdTdT. 5′ thiol-modified for polymerization to poly-siRNA.; 5' thiol-modified for polymerization to poly-siRNA; 5' thiol; dTdT; 3' dTdT/TT overhang