siRNA

Linked experiment: EXP001731

Linked peptide: iRGD TPN (PEGylated) therapeutic dosing [15:2.5:1 pTP-TAM-iRGD:pTP-PEG(5k)-iRGD:siKras]

Linked paper: iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer (2018)

RNA overview

RNA Type: siRNA
Payload/target: siLuc
Target gene/transcript: Kras; anti-Kras

Sequence information

Sequence reported in source article: yes
RNA sequence: sense:ACCAUUAUAGAGAACAAAUUA
Sense strand: ACCAUUAUAGAGAACAAAUUA
Antisense strand

Chemical modifications

RNA modifications: siKras.476 (targets murine+human KRAS) sense (no overhangs): ACCAUUAUAGAGAACAAAUUA