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aptamer

Linked experiment: EXP001806

Linked peptide: MRP/R8-modified MITO-Porter (2.5 mol% Chol-MRP)

Linked paper: A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting (2016)

RNA overview

RNA Type

aptamer

Payload/target

Mitochondrial targeting (RP/MRP/D-arm aptamer as targeting ligand); no gene-silencing payload delivered

Target gene/transcript

ligand

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:AGAAGCGUAUCCCGCUGAGC

Sense strand

AGAAGCGUAUCCCGCUGAGC

Antisense strand

Chemical modifications

RNA modifications

5′-AGAAGCGUAUCCCGCUGAGC-3′ (2′-O-methyl RNA; Cholesterol at 3′ end)