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siRNA

Linked experiment: EXP001825

Linked peptide: CPP-LSP/siRNA physical mixture (LMWP-AANL + siRNA complex)

Linked paper: Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA (2021)

RNA overview

RNA Type

siRNA

Payload/target

EGFP knockdown (anti-EGFP siRNA) in HCT116-EGFP cells

Target gene/transcript

EGFP

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:GGCUACGUCCAGGAGCGCAdTdT; antisense:UGCGCUCCUGGACGUAGCCdTdT

Sense strand

GGCUACGUCCAGGAGCGCAdTdT

Antisense strand

UGCGCUCCUGGACGUAGCCdTdT

Chemical modifications

RNA modifications

5′-GGCUACGUCCAGGAGCGCAdTdT-/3thiol/3 (antisense: 5′-UGCGCUCCUGGACGUAGCCdTdT-3′)