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siRNA

Linked experiment: EXP001828

Linked peptide: Ab-CPP-LSP-siRNA-Cy3 (ARC; cetuximab–PEG–LMWP–AANL–siRNA)

Linked paper: Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA (2021)

RNA overview

RNA Type

siRNA

Payload/target

EGFP knockdown in xenograft tumors (in vivo gene silencing)

Target gene/transcript

EGFP

Sequence information

Sequence reported in source article

no

RNA sequence

not reported

Sense strand

Antisense strand

Chemical modifications

RNA modifications

Cy3-labeled anti-EGFP siRNA used for tumor section imaging + quantification; anti-EGFP siRNA for silencing.