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ASO

Linked experiment: EXP001847

Linked peptide: HIV-1 Tat CPP (recombinant Tat peptide)

Linked paper: Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator (2019)

RNA overview

RNA Type

ASO

Payload/target

BGas (CFTR-AS1) lncRNA knockdown to activate CFTR transcription (gapmer 10, G10; targets BGas intron 1)

Target gene/transcript

not reported

Sequence information

Sequence reported in source article

no

RNA sequence

not reported

Sense strand

Antisense strand

Chemical modifications

RNA modifications

20-nt gapmer with phosphorothioate (PS) bonds: 3 PS at both 5′ and 3′ ends surrounding an unmodified DNA-like gap; scramble control also PS-modified.