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siRNA

Linked experiment: EXP001850

Linked peptide: Cholesterol-DP7-ACP-T7 (DAT) (dual-functional peptide on liposome)

Linked paper: A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy (2024)

RNA overview

RNA Type

siRNA

Payload/target

slit2 (si slit2) knockdown in glioma (GL261); targets migration/invasion and modulates immune microenvironment

Target gene/transcript

not reported

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:GCCACGGGAAUAUUUAAGATT; antisense:UCUUAAAUAUUCCCGUGGCTT

Sense strand

GCCACGGGAAUAUUUAAGATT

Antisense strand

UCUUAAAUAUUCCCGUGGCTT

Chemical modifications

RNA modifications

Sense: 5′-GCCACGGGAAUAUUUAAGATT-3′; Antisense: 5′-UCUUAAAUAUUCCCGUGGCTT-3′. NC siRNA also used.