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siRNA

Linked experiment: EXP002385

Linked peptide: Tat

Linked paper: Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles (2019)

RNA overview

RNA Type

siRNA

Payload/target

TNF-α

Target gene/transcript

TNF

Sequence information

Sequence reported in source article

yes

RNA sequence

sense:AAGAGAACCUGGGAGUAGAUAAGGUTT

Sense strand

AAGAGAACCUGGGAGUAGAUAAGGUTT

Antisense strand

Chemical modifications

RNA modifications

dTdT overhangs; 3' dTdT/TT overhang