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siRNA

Linked experiment: EXP002449

Linked peptide: Penetratin-siRNA

Linked paper: Lung Delivery Studies Using siRNA Conjugated to TAT(48-60) and Penetratin Reveal Peptide Induced Reduction in Gene Expression and Induction of Innate Immunity (2007)

RNA overview

RNA Type

siRNA

Payload/target

p38 MAP kinase siRNA sequence C

Target gene/transcript

p38 MAP kinase / MAPK14

Sequence information

Sequence reported in source article

yes

RNA sequence

sense: 5′-GGGAGGUGCCCGAACGAUAUidT-3′; antisense: 5′-UAUCGUUCGGGCACCUCCCUidT-3′

Sense strand

GGGAGGUGCCCGAACGAUAU

Antisense strand

UAUCGUUCGGGCACCUCCCU

Chemical modifications

RNA modifications

siRNA duplex sequence C; peptide conjugated to 5′ end of sense strand through C6-thiol/disulfide linker; idT terminal residue reported in conjugate methods