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ASO

Linked experiment: EXP002485

Linked peptide: N-terminal GGC 22A ApoA1 mimetic peptide / NNA5

Linked paper: Nanodiscoidal Nucleic Acids for Gene Regulation (2023)

RNA overview

RNA Type

ASO

Payload/target

HIF-1α ASO (EZN2968)

Target gene/transcript

HIF1A / HIF-1α mRNA

Sequence information

Sequence reported in source article

yes

RNA sequence

+T*+G*+G*C*A*A*G*C*A*T*C*C*+T*+G*+T*A

Sense strand

Antisense strand

+T*+G*+G*C*A*A*G*C*A*T*C*C*+T*+G*+T*A

Chemical modifications

RNA modifications

EZN2968 anti-HIF-1α ASO; LNA-modified bases indicated by '+', phosphorothioate linkages indicated by '*'; amine/maleimide-conjugated to nanodisc in ASO-ND/NNA constructs