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SCO

Linked experiment: EXP002547

Linked peptide: Met16

Linked paper: Introducing a Single-Point Modification to the Cell-Penetrating Peptide PepFect14 Analogue Sequence for Optimising Oligonucleotide Delivery (2025)

RNA overview

RNA Type

SCO

Payload/target

SCO-705 and Cy5-SCO-654 reporter SCOs

Target gene/transcript

splice-correction reporter constructs in HeLa pLuc-705 and HeLa-eGFP-654 cells

Sequence information

Sequence reported in source article

yes

RNA sequence

SCO-705: CCUCUUACCUCAGUUACA; SCO-654/Cy5-SCO-654: GCUAUUACCUAAACCCAG

Sense strand

CCUCUUACCUCAGUUACA; GCUAUUACCUAAACCCAG

Antisense strand

Chemical modifications

RNA modifications

phosphorothioate backbone and 2′-O-methyl modification; Cy5 label used for SCO-654 uptake/internalization experiments