Back to browse

PNA (antisense oligonucleotide; 20-mer)

Linked experiment: EXP000987

Linked peptide: ApoE(140-150) CPP – thiol–maleimide linkage (C3)

Linked paper: Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates (2019)

RNA fields

RNA Type

PNA (antisense oligonucleotide; 20-mer)

RNA Payload Or Target

SMN2 pre-mRNA splice correction (promote exon 7 inclusion; full-length SMN2 transcript)

RNA Modifications

PNA sequence 5'-ATTCACTTTCATAATGCTGG-3' with N-terminal miniPEG spacer and functional group for ligation; 5'-maleimide (maleimidopropionic acid; PNA-1)