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PNA (antisense oligonucleotide; 20-mer)

Linked experiment: EXP000988

Linked peptide: ApoE(140-150) CPP – thiol–CBT linkage (C4)

Linked paper: Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates (2019)

RNA fields

RNA Type

PNA (antisense oligonucleotide; 20-mer)

RNA Payload Or Target

SMN2 pre-mRNA splice correction (promote exon 7 inclusion; full-length SMN2 transcript)

RNA Modifications

PNA sequence 5'-ATTCACTTTCATAATGCTGG-3' with N-terminal miniPEG spacer and functional group for ligation; 5'-cysteine (PNA precursor used for thiol–CBT ligation)