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antisense oligonucleotide analogue (anti-TAR)

Linked experiment: EXP001575

Linked peptide: Tat (48–58)

Linked paper: Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides (2005)

RNA fields

RNA Type

antisense oligonucleotide analogue (anti-TAR)

RNA Payload Or Target

HIV-1 TAR RNA (steric block of Tat/TAR; reporter assay) | 12mer 2'-O-methyl/LNA mixmer anti-TAR: 5'-CUC CCA GGC UCA-3' (mixmer; 3' fluorescein; 5' C6-thiol linker)

RNA Modifications

3' fluorescein label; 5' C6-thiol linker; OMe/LNA mixmer or phosphorothioate as specified.