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siRNA

Linked experiment: EXP001885

Linked peptide: Penetratin — NPs-2 (HA 200 kDa, low density shell)

Linked paper: Fine Tuning of Core–Shell Structure of Hyaluronic Acid/Cell-Penetrating Peptides/siRNA Nanoparticles for Enhanced Gene Delivery to Macrophages in Antiatherosclerotic Therapy (2018)

RNA fields

RNA Type

siRNA

RNA Payload Or Target

LOX-1 (lectin-like oxLDL receptor-1) siRNA

RNA Modifications

Human LOX-1 siRNA: 5′-AGGACGGUUCUCCUUUGAU dTdT-3′ (and complement). Mouse LOX-1 siRNA: 5′-GUGGCCAGUUACUACAAAU dTdT-3′ (and complement). Controls: siNonsense; Cy3/Cy5 labeled on 5′ sense strand for uptake/imaging.