Sequence: H(Aib)EGTFTSDVSSYLEEQAAKEFIAWLVKGGPSSGAPPPSC
| Experiment Id | EXP002470 |
|---|---|
| Paper | Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pan |
| Peptide | eGLP-1-C / FOXO1 ASO 3b |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | covalent peptide-ASO conjugate |
| Formulation Format | GLP1R agonist peptide-ASO conjugate |
| Formulation Components | GLP1R agonist peptide ligand covalently conjugated to cEt BNA/DNA gapmer ASO via indicated linker |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 mice; isolated pancreatic islets analyzed |
| Administration Route | subcutaneous; once weekly for 2 weeks at 0.2, 0.07, or 0.02 μmol/kg |
| Output Type | IAPP mRNA knockdown in pancreatic islets |
| Output Value | Robust inhibition of IAPP mRNA; ED50 reported as 0.006 μmol/kg |
| Output Units | |
| Output Notes | Functional in vivo RNA knockdown in isolated pancreatic islets; positive delivery label. |
| Toxicity Notes | |
| Curation Notes |