eGLP-1-C / FOXO1 ASO 3b

Peptide ID: PEPTIDE001890
Raw sequence: H(Aib)EGTFTSDVSSYLEEQAAKEFIAWLVKGGPSSGAPPPSC
Clean backbone: H[AIB]EGTFTSDVSSYLEEQAAKEFIAWLVKGGPSSGAPPPSC
Tokenized backbone: H-AIB-E-G-T-F-T-S-D-V-S-S-Y-L-E-E-Q-A-A-K-E-F-I-A-W-L-V-K-G-G-P-S-S-G-A-P-P-P-S-C
Sequence engineering: Chimeric GLP1R agonist based on hGLP1 N-terminus and Exendin-4 C-terminal tail; Aib substitution; C-terminal cysteine conjugation handle
Stereochemistry: L-amino acids; Aib is noncanonical achiral α,α-disubstituted residue
Modifications: C-terminal cysteine; disulfide linker to FOXO1 ASO with d(TmCA) spacer
Sequence length: 44
Noncanonical residues

Experiments