Sequence: CKRRMKWKKC
| Experiment Id | EXP001175 |
|---|---|
| Paper | Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize |
| Peptide | CPP |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | Covalent CPP-siRNA conjugate |
| Rna Concentration | 1.2 mg/kg (siRNA equivalent) |
| Mixing Ratio | 1:1 (covalent conjugate) |
| Formulation Format | Free C-siRNA (CPP–siRNA conjugate) (no carrier) |
| Formulation Components | CPP disulfide-linked to thiol-modified Bcl-2 siRNA (C-siRNA); administered IV |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Male nude mice bearing subcutaneous HepG2 tumor xenografts |
| Administration Route | Intravenous (tail vein); tumor region heated to 42°C for 30 min after injection (except U group). |
| Output Type | Tumor growth inhibition (in vivo) |
| Output Value | No tumor inhibition vs control; non-specific distribution and fast elimination |
| Output Units | |
| Output Notes | In vivo distribution resembled free siRNA (systemic, bladder/kidney clearance); no evident tumor targeting or tumor suppression. |
| Toxicity Notes | |
| Curation Notes |