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siRNA

Linked experiment: EXP001175

Linked peptide: CPP

Linked paper: Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells (2022)

RNA fields

RNA Type

siRNA

RNA Payload Or Target

Bcl-2 siRNA therapy attempt in HepG2 xenograft tumors

RNA Modifications

Bcl-2 siRNA duplex (sense 5′-GUGAUGAAGUACAUCCAUUdTdT-3′; antisense 5′-AAUGGAUGUACUUCAUCACdTdT-3′); CPP conjugated via disulfide to thiol-modified sense (C-siRNA).