iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer

Paper ID: PAPER000320
Year: 2018
DOI: 10.1158/1535-7163.mct-17-1090
PMID: 30097486
Journal: Molecular Cancer Therapeutics
Source URL

Experiments

EXP001875 with iRGD TPN (PEGylated) [pTP-iRGD + pTP-PEG-iRGD] (siRNA)
EXP001876 with iRGD TPN (PEGylated) [15:2.5:1 pTP-TAM-iRGD:pTP-PEG(5k)-iRGD:siRNA] (siRNA)
EXP001877 with iRGD TPN (PEGylated) therapeutic dosing [15:2.5:1 pTP-TAM-iRGD:pTP-PEG(5k)-iRGD:siKras] (siRNA)
EXP001878 with iRGD TPN (PEGylated vs non-PEG) biodistribution (healthy mice) (siRNA)