iRGD TPN (PEGylated) [15:2.5:1 pTP-TAM-iRGD:pTP-PEG(5k)-iRGD:siRNA]

Peptide ID: PEPTIDE001418
Raw sequence: Palmitoyl-transportan-iRGD (pTP-TAMRA-iRGD): CH3(CH)15-[GWTLNSAGYLLGKINLKALAALAKKIL-GGK(TAMRA)GGCRGDKGPDC] (Cys-Cys bridge) ; Palmitoyl-transportan-PEG(5kDa)-iRGD (pTP-PEG-iRGD): (CH3(CH)15-[GWTLNSAGYLLGKINLKALAALAKKILC]-S-S-PEG(5kDa)-X-[GGGCRGDKGPDC] (Cys-Cys bridge))
Clean backbone: GWTLNSAGYLLGKINLKALAALAKKILCGGGCRGDKGPDC
Tokenized backbone: G-W-T-L-N-S-A-G-Y-L-L-G-K-I-N-L-K-A-L-A-A-L-A-K-K-I-L-C-G-G-G-C-R-G-D-K-G-P-D-C
Sequence engineering
Stereochemistry
Modifications: N-terminal saturated fatty acid (palmitic acid) on transportan CPP; iRGD is cyclized via Cys-Cys bridge; TAMRA label in pTP-TAM-iRGD; PEG(5kDa) spacer in pTP-PEG-iRGD (disulfide linkage to CPP).
Sequence length: 40
Noncanonical residues

Experiments