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A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting

Paper ID

PAPER000325

Year

2016

DOI

10.1016/j.xphs.2016.03.002

PMID

27056631

Journal

Journal of Pharmaceutical Sciences

Source URL

Experiments

• EXP001951 with R8-modified MITO-Porter (no RNA aptamer) (RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload])
• EXP001952 with RP/R8-modified MITO-Porter (2.5 mol% Chol-RP) (RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload])
• EXP001953 with MRP/R8-modified MITO-Porter (2.5 mol% Chol-MRP) (RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload])
• EXP001954 with D-arm/R8-modified MITO-Porter (2.5 mol% Chol-D-arm) (RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload])