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D-arm/R8-modified MITO-Porter (2.5 mol% Chol-D-arm)

Peptide ID

PEPTIDE001492

Raw sequence

RRRRRRRR

Clean backbone

RRRRRRRR

Tokenized backbone

R-R-R-R-R-R-R-R

Sequence engineering

Stereochemistry

L-form

Modifications

Stearylated R8 (lipidated octaarginine) attached to MITO-Porter surface (10 mol% of total lipids). Dual-ligand variants include Chol-aptamer inserted into lipid membrane (2.5 mol% of total lipids): 5′-GGGACUGUAGCUCAAUUGGUAGAGCAU-3′ (2′-O-methyl RNA; Cholesterol at 3′ end)

Sequence length

8

Noncanonical residues

Experiments

• EXP001954 from A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mit…