PPP (activated)

Peptide ID: PEPTIDE000692
Raw sequence: CGRRMKWKK-[photo]-EEEERRRR
Clean backbone: CGRRMKWKKEEEERRRR
Tokenized backbone: C-G-R-R-M-K-W-K-K-E-E-E-E-R-R-R-R
Sequence engineering
Stereochemistry: L-form
Modifications: Dual-responsive polypeptide (PPP): CPP segment CGRRMKWKK + photo-cleavable 4,5-dimethoxy-2-nitrobenzyl linker + pH-sensitive inhibitory peptide EEEERRRR; conjugated to DSPE-PEG2000 (maleimide–Cys); displayed on PLGA NP surface (10 mol% DSPE-PEG2000-PPP; screened 5/10/20 mol%). NIR activation 740 nm (50 J/cm^2, 30 min); pH 6.0 required for deshielding.
Sequence length: 17
Noncanonical residues

Experiments