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9R (C3G9R4LC) + Cas9-m9R system

Peptide ID
PEPTIDE001073
Raw sequence
GGGGRRRRRRRRRLLLLC
Clean backbone
GGGGRRRRRRRRRLLLLC
Tokenized backbone
G-G-G-G-R-R-R-R-R-R-R-R-R-L-L-L-L-C
Sequence engineering
Stereochemistry
Modifications
Cas9 protein engineered with C-terminal cysteine and tagged (His/HA) then conjugated to maleimide-linked CPP (m9R = GGGGRRRRRRRRRLLLL) via thioether bond; sgRNA noncovalently complexed with 9R peptide (9R = CGGGRRRRRRRRRLLLLC) to form positively charged nanoparticles.
Sequence length
18
Noncanonical residues

Experiments