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ASO

Linked experiment: EXP001638

Linked peptide: pAntp / Penetratin (Antennapedia 43–58)

Linked paper: Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo (1998)

RNA overview

RNA Type

ASO

Payload/target

Scrambled PNA 21-mer-S–S-pAntp (control; intrathecal)

Target gene/transcript

not reported

Sequence information

Sequence reported in source article

yes

RNA sequence

sense: PNA (peptide nucleic acid; antisense); antisense: Scrambled PNA 21-mer-S–S-pAntp (control; intrathecal)

Sense strand

Antisense strand

Scrambled PNA 21-mer-S–S-pAntp (control; intrathecal)

Chemical modifications

RNA modifications

21-mer PNA; biotinylated at PNA N-terminus for localization in some experiments; coupled to peptide via disulfide (S–S) through cysteine-extended PNA.