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siRNA

Linked experiment: EXP002478

Linked peptide: WRAP5

Linked paper: In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery (2021)

RNA overview

RNA Type

siRNA

Payload/target

siFluc / firefly luciferase siRNA

Target gene/transcript

Firefly luciferase (Fluc) reporter mRNA

Sequence information

Sequence reported in source article

yes

RNA sequence

siFluc: CUUACGCUGAGUACUUCGA(dTdT) | siSCR control: AGCUUCAUGAGUCGCAUU(dTdT)

Sense strand

CUUACGCUGAGUACUUCGA(dTdT); AGCUUCAUGAGUCGCAUU(dTdT)

Antisense strand

Chemical modifications

RNA modifications

siRNA; fluorescent Alexa790/Cy3-labeled siFluc used for imaging in selected experiments; no stabilizing backbone modification reported.